Skip to Main content Skip to Navigation
Journal articles

Transfer and Transcriptomic Profiling in Liver and Brain of European Eels ( Anguilla anguilla ) After Diet‐borne Exposure to Gold Nanoparticles

Abstract : A nanometric revolution is underway, promising technical innovations in a wide range of applications and leading to a potential boost in environmental discharges. The propensity of nanoparticles (NPs) to be transferred throughout trophic chains and to generate toxicity was mainly assessed in primary consumers, whereas a lack of knowledge for higher trophic levels persists. The present study focused on a predatory fish, the European eel (Anguilla anguilla) exposed to gold NPs (AuNPs; 10 nm, polyethylene glycol–coated) for 21 d at 3 concentration levels in food: 0 (NP0), 1 (NP1), and 10 (NP10) mg Au kg−1. Transfer was assessed by Au quantification in eel tissues, and transcriptomic responses in the liver and brain were revealed by a high‐throughput RNA‐sequencing approach. Eels fed at NP10 presented an erratic feeding behavior, whereas Au quantification only indicated transfer to intestine and kidney of NP1‐exposed eels. Sequencing of RNA was performed in NP0 and NP1 eels. A total of 258 genes and 156 genes were significantly differentially transcribed in response to AuNP trophic exposure in the liver and brain, respectively. Enrichment analysis highlighted modifications in the immune system–related processes in the liver. In addition, results pointed out a shared response of both organs regarding 13 genes, most of them being involved in immune functions. This finding may shed light on the mode of action and toxicity of AuNPs in fish.
Document type :
Journal articles
Complete list of metadatas

Cited literature [108 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-02975506
Contributor : Stéphane Toulin <>
Submitted on : Monday, October 26, 2020 - 3:29:46 PM
Last modification on : Friday, November 6, 2020 - 9:24:04 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : 2021-08-24

Please log in to resquest access to the document

Identifiers

Collections

Citation

Fanny Perrier, Anthony Bertucci, Fabien Pierron, Agnès Feurtet‐mazel, Olivier Simon, et al.. Transfer and Transcriptomic Profiling in Liver and Brain of European Eels ( Anguilla anguilla ) After Diet‐borne Exposure to Gold Nanoparticles. Environmental Toxicology and Chemistry, Wiley, In press, ⟨10.1002/etc.4858⟩. ⟨hal-02975506⟩

Share

Metrics

Record views

51